Tetrahedron Letters 2018-04-10

Microwave promoted reaction of purin-6-yl magnesium halides with aldehydes in dichloromethane at 100 °C

Malcolm R. Gordon, Stephen D. Lindell

Index: 10.1016/j.tetlet.2018.04.014

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Abstract

Treatment of a dichloromethane solution of 9-benzyl or 9-phenyl 6-iodopurine with ethereal ethylmagnesium bromide at ambient temperature gives the corresponding purin-6-yl magnesium halides. Addition of an aldehyde followed by heating at 100 °C in a microwave reactor yielded the corresponding carbinols in 52-81% yield.