Organic Chemistry Frontiers 2018-03-29

Copper/amine-catalyzed formal regioselective [3 + 2] cycloaddition of an α,β-unsaturated O-acetyl oxime with enals

Ying Xie, Yulong Li, Xun Chen, Yingle Liu, Wei Zhang

Index: 10.1039/C8QO00204E

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Abstract

A novel copper/amine co-catalyzed formal regioselective [3 + 2] cycloaddition reaction of an O-acyl oxime with α,β-unsaturated aldehydes is developed. This novel transformation provided an efficient protocol for the assembly of multifunctionalized pyrroles with good yields and diverse functional group tolerance.