Synlett 2018-03-28

Synthesis of Nepetoidin B

Timokhin, Vitaliy, Regner, Matthew, Tsuji, Yukiko, Grabber, John, Ralph, John

Index: 10.1055/s-0036-1591556

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Abstract

The first synthesis of nepetoidin B in an overall yield of 17% was achieved in two steps through Baeyer–Villiger oxidation of commercially available 1,5-bis(3,4-dimethoxyphenyl)-1,4-pentadien-3-one with oxone to produce the tetramethylated nepetoidin B, followed by demethylation using boron tribromide.