In connection with other work in progress it became necessary to synthesize a number of hitherto unreported a-and phenyl-substituted acetoacetanilides, and from these the corresponding 4-methylcarbostyrils. The former were prepared by previously described alkylations of acetoacetanilide1r2 and by acetoacetylation of aromatic amine^,^ the
[Blackburn, Thomas P.; Cox, Barry; Guildford, Allen J.; Count, David J. Le; Middlemiss, Derek N.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2252 - 2259]
