Tetrahedron 2018-03-09

Copper-catalyzed efficient synthesis of 5-arylindazolo[3,2-b]quinazolin-7(5H)-ones from 2-nitrobenzaldehydes

Zahra Arasteh Fard, Karim Akbari Dilmaghani, Mehdi Soheilizad, Bagher Larijani, Mohammad Mahdavi

Index: 10.1016/j.tet.2018.03.018

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Abstract

A novel and practical copper-catalyzed approach was developed for the preparation of 5-arylindazolo[3,2-b]quinazolin-7(5H)-ones. The 2-amino-N′-arylbenzohydrazideis easily prepared by a reaction of isatoic anhydride with arylhydrazine. Then, through a condensation/intramolecular cyclization reaction by 2-nitrobenzaldehydes in the present of CuI, the corresponding 5-arylindazolo[3,2-b]quinazolin-7(5H)-ones are produced in good yields.