Tetrahedron 2018-03-07

Facile synthesis of perfluoroalkylated fluorenes via a one-pot two-step three-component process

Zhenhua Sun, Qi Huang, Jing Han, Weimin He, Jie Chen, Yuchen Xu, Hongmei Deng, Min Shao, Hui Zhang, Weiguo Cao

Index: 10.1016/j.tet.2018.03.012

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Abstract

The efficient synthesis of perfluoroalkyl-substituted fluorenes directly from indenones, malononitrile and methyl perfluoroalk-2-ynoates via a one-pot two-step three-component cascade process is reported. Up to 12 examples of indenones with various substituents were converted into their corresponding functionalized fluorene derivatives in good to excellent yields.