Bioorganic & medicinal chemistry letters

Acylcyclohexanedione derivatives as potential in vivo sequential inhibitors of 4-hydroxyphenylpyruvate dioxygenase and GA 20 3β-hydroxylase

JL Huang, HG Liu, DY Yang

Index: Huang, Jian-Lin; Liu, Hun-Ge; Yang, Ding-Yah Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 5 p. 927 - 930

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Citation Number: 4

Abstract

Acylcyclohexanedione derivatives have been designed, synthesized, and evaluated for in vitro inhibition activity against the enzyme 4-hydroxyphenylpyruvate dioxygenase (4-HPPD). The biological data demonstrated that 7 is a potent inhibitor of 4-HPPD with an IC50 value of 40nM. After metabolism, compound 7 has the potential to become a potent inhibitor of a second enzyme, GA20 3β-hydroxylase.