Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers

…, Y Song, JK Inman, M Huang, A Wallqvist…

Index: Turpin, Jim A.; Song, Yongsheng; Inman, John K.; Huang, Mingjun; Wallqvist, Anders; Maynard, Andrew; Covell, David G.; Rice, William G.; Ettore, Appella Journal of Medicinal Chemistry, 1999 , vol. 42, # 1 p. 67 - 86

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Citation Number: 115

Abstract

Nucleocapsid p7 protein (NCp7) zinc finger domains of the human immunodeficiency virus type 1 (HIV-1) are being developed as antiviral targets due to their key roles in viral replication and their mutationally nonpermissive nature. On the basis of our experience with symmetrical disulfide benzamides (DIBAs; Rice et al. Science 1995, 270, 1194-1197), we synthesized and evaluated variants of these dimers, including sets of 4, 4'-and 3, 3'- ...