Conformationally Controlled Odor Perception in 'Steroid??type'Scent Molecules

…, W Giersch, W Thommen, B Willhalm

Index: Ohloff, Guenther; Giersch, Wolfgang; Thommen, Walter; Willhalm, Bruno Helvetica Chimica Acta, 1983 , vol. 66, # 5 p. 1343 - 1354

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Citation Number: 28

Abstract

Abstract A series of compounds possessing a 'Steroid-type'scent and related to 4-(4′-t- butylcyclohexyl)-4-methyl-2-pentanones (1 and 2) has been synthesized. The odor of these compounds has been found to be dependent on their conformation; only when the molecule can assume a steroid-like shape there is an interaction with the odor chemoreceptor.