Studies on 1, 2, 3,-triazoles. 10. Synthesis and antiallergic properties of 9-oxo-1H, 9H-benzothiopyrano [2, 3-d]-1, 2, 3-triazoles and their s-oxides

DR Buckle, CJM Rockell, H Smith…

Index: Buckle, Derek R.; Rockell, Caroline J. M.; Smith, Harry; Spicer, Barbara A. Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 223 - 227

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Citation Number: 27

Abstract

Drug solutions were prepared in distilled water and administered in a 0.2-mL subcutaneous dose. Infected animals received one dose 4 h postinfection and two doses daily for 2 days on the side opposite the infected site. Mice were examined 7 days after infection for the presence or absence of abscesses, evident by palpation. The median protective dose (CD,,), ie, the amount of drug required to protect 50% of the animals from abscess formation, was ...