e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the …
A De Mesmaeker, S Wendeborn, C Jouanno…
Index: De Mesmaeker, Alain; Wendeborn, Sebastian; Jouanno, Chantal; Fritsch, Valerie; Wolf, Romain M. Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 14 p. 1869 - 1874
The synthesis of the amide dimers 3–5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures (Tm's) of the corresponding duplexes with RNA-and DNA-complements, and a summary of molecular modeling studies.
