2, 4-Dialkyl-8, 9, 10, 11-tetrahydrobenzo [g] pyrimido [4, 5-c] isoquinoline-1, 3, 7, 12 (2H, 4H)-tetraones as new leads against Mycobacterium tuberculosis

P Claes, D Cappoen, C Uythethofken, J Jacobs…

Index: Claes, Pieter; Cappoen, Davie; Uythethofken, Cynthia; Jacobs, Jan; Mertens, Birgit; Mathys, Vanessa; Verschaeve, Luc; Huygen, Kris; De Kimpe, Norbert European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 409 - 421

Full Text: HTML

Citation Number: 15

Abstract

Abstract Given the re-emergence of tuberculosis in Europe and beyond, the search for novel bio-active compound classes against this disease is of utmost importance. As a result of a high intrinsic tolerance of the etiological agent, Mycobacterium tuberculosis, towards most antibiotics and xenobiotics, the search for such new compounds is far from trivial. Further exacerbated by the rapid generation and spread of drug resistant M. tuberculosis and ...