DACTHF). Benzene ring substituted analogues were synthesized from a protected pyrimidinyl propionaldehyde and a substituted benzoyl glutamate moiety by a key reductive amination step. Pyrimidine and linking chain subetituted analogues were built up stepwise from p-aminobenzoic acid or analogues. The compounds were teated as inhibitors of methotrexate uptake as a measure of binding to the reduced folate tramport system, as ...
