Synthesis, cytotoxicity against human oral cancer KB cells and structure–activity relationship studies of trienone analogues of curcuminoids

T Chuprajob, C Changtam, R Chokchaisiri…

Index: Chuprajob, Thipphawan; Changtam, Chatchawan; Chokchaisiri, Ratchanaporn; Chunglok, Warangkana; Sornkaew, Nilubon; Suksamrarn, Apichart Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 13 p. 2839 - 2844

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Citation Number: 11

Abstract

Abstract A general method for the synthesis of substituted (1E, 4E, 6E)-1, 7-diphenylhepta-1, 4, 6-trien-3-ones, based on the aldol condensations of substituted 4-phenylbut-3-en-2-ones and substituted 3-phenylacrylaldehydes, was achieved. The natural trienones 4 and 5 have been synthesized by this method, together with the trienone analogues 9–20. These analogues were evaluated for their cytotoxic activity against human oral cancer KB cell ...