UnyLinker: An efficient and scaleable synthesis of oligonucleotides utilizing a universal linker molecule: A novel approach to enhance the purity of drugs

VT Ravikumar, RK Kumar, P Olsen…

Index: Jankowska, Jadwiga; Stawinski, Jacek Synthesis, 1984 , # 5 p. 408 - 410

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Citation Number: 6

Abstract

... based on norbornylene (6), 5-norbornene-2-carboxylic acid (7), and 5-norbornene-2 ... We proposed 12 to be an optimally designed molecule for efficient synthesis of oligonucleotides. Thus, UnyLinker 12 was synthesized and loaded onto various solid supports and evaluated for ...

~45%

~76%

~81%

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