A new chemical tool for exploring the physiological function of the PDE2 isozyme

…, AL Sheils, DA Tess, AS Vellekoop, Y Zhang…

Index: Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310

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Citation Number: 30

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2. ... Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and ...