A highly convergent, scalable synthesis of the rebeccamycin analog 2 was demonstrated in seven steps and 31% overall yield based on the N-protected building block dibromomaleimide 7. The practical synthesis of other two building blocks, 5, 6-difluoro-3- benzothiopheneboronic acid 6 and 5, 6-difluoroindole 8, is described.
