Targeting carnitine biosynthesis: discovery of new inhibitors against γ-butyrobetaine hydroxylase

K Tars, J Leitans, A Kazaks, D Zelencova…

Index: Olah, George A.; Karpeles, Richard; Narang, Subhash C. Synthesis, 1982 , # 11 p. 963 - 965

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Citation Number: 13

Abstract

... Targeting Carnitine Biosynthesis: Discovery of New Inhibitors against γ-Butyrobetaine Hydroxylase. ... (d) Amberlite IRA-410 (OH). (e) Aqueous HCl, dioxane, 40–70 °C, yield 70% (on 5d). Alicyclic methylamines 30a–c, necessary for the synthesis of aminobutanoates 5a–c ...