1-Acetyl-2-bromo-3-indolinone in nucleophilic substitution reactions and the synthesis of pyrrolo [3, 2-b] indoles

…, AI Mel'man, YI Smushkevich, VI Pol'shakov…

Index: Velezheva, V. S.; Mel'man, A. I.; Smushkevich, Yu. I.; Pol'shakov, V. I.; Anisimova, O. S. Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 12 p. 917 - 923 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 12 p. 46 - 51

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Abstract

Indoles with 2, 3-disubstitution and heterocycles obtained from them are of interest in the search for new biologically active materials [4, 9]. One of the possible approaches to the synthesis of compounds of such structure is in the use of 2-substituted indoxyls [i, 6]. The present work presents a new method for the introduction of nucleophilic substituents into position 2 of indoxyl and its subsequent conversion into hetero [b] indoles, and in ...