… -6-methyldipyrido [1, 2-a: 3', 2'-d] imidazole isolated from a glutamic acid pyrolysate: structure of the modified nucleic acid base and initial chemical event caused by …

Y Hashimoto, K Shudo, T Okamoto

Index: Hashimoto, Yuichi; Shudo, Koichi; Okamoto, Toshihiko Journal of the American Chemical Society, 1982 , vol. 104, # 26 p. 7636 - 7640

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Citation Number: 61

Abstract

Results Covalent Binding of Glu-P-1 with DNA. Glu-P-1 shows very high mutagenic activity toward Salmonella typhimurium TA 98 in the presence of microsomal proteins. Consistent with this fact, Glu-P-1 binds to DNA only in the presence of microsomes. This binding is covalent, since reprecipitation, gel filtration, or dialysis of the mutagen-DNA complex do not liberate free Glu-P-1. The amount of Glu-P-1 bound to DNA was enhanced by addition of ...