Derivatives of aminophenylacetic acid and their antineoplastic activity

…, GL Papayan, AA Chachoyan, KG Samvelyan

Index: Davtyan, S. M.; Papayan, G. L.; Chachoyan, A. A.; Samvelyan, K. G. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 7 p. 517 - 519 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 7 p. 794 - 796

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Abstract

The toxicity of the substances was determined on noninbred white mice of both sexes, weighing 18-20 g, with a single intraperitoneal injection. The antineoplastic activity was studied on noninbred white rats with sarcoma 45, Shvets leukemia, and Piiss lymphosarcoma (dose 1/25 of LDxoo, eight daily injections) and mice with sarcoma 180 and Ehrlich's ascites carcinoma (dose i/i0 of LD, oo, six daily injections). The compounds in the ...