Abstract: Four scries of new l-aryi (heteroaryl) piperazinylacelyl derivatives of IH, 3H-pyrido| 2, 3-i/l pyrimidin^ t-one УИа_ „were synthesised. Substrates for the synthesis of VI^ were obtained from the respective 3H-pyrido [2, 3-c/jpyrimidines IVa_,| in the reaction with NaBH4, Compounds VIa „C| were prepared by chloroacetylation. The obtained 1- chloroacetyl derivatives in the reaction with respective aryl (heteroaryl) pjperazine formed ...