SYNTHESIS AND CONFORMATION ANALYSIS OF 3-SUBSTITUTED DERIVATIVES OF lH, 3H-PYRIDO [2, 3-¿/] PYRlMIDIN^ kONE OF EXPECTED …

A Chodkowski, F Herold…

Index: Chodkowski, Andrzej; Herold, Franciszek; Kleps, Jerzy Acta Poloniae Pharmaceutica - Drug Research, 2004 , vol. 61, # 1 p. 45 - 53

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Abstract

Abstract: Four scries of new l-aryi (heteroaryl) piperazinylacelyl derivatives of IH, 3H-pyrido| 2, 3-i/l pyrimidin^ t-one УИа_ „were synthesised. Substrates for the synthesis of VI^ were obtained from the respective 3H-pyrido [2, 3-c/jpyrimidines IVa_,| in the reaction with NaBH4, Compounds VIa „C| were prepared by chloroacetylation. The obtained 1- chloroacetyl derivatives in the reaction with respective aryl (heteroaryl) pjperazine formed ...