A catalytic asymmetric cyclopropanation of enol silyl ether 9 gave the lactone 3 in up to 78% ee. The lactone 3 was then transformed into 2, potentially a very versatile intermediate for phorbol analogs, using an intramolecular nitrile oxide cycloaddition as a key step. ... Compound 13 was obtained as a mixture (trans:cis=1:1). ... The stereochemistry was determined by NOE experiments of 25. ... Cookies are used by this site. To decline or learn more, visit our Cookies page.
