2, 4-Thiazolidinedione derivatives of 1, 3-benzoxazinone were synthesized and evaluated for their PPAR-α and-γ dual activation. DRF-2519, a compound obtained through SAR of TZD derivatives of benzoxazinone, has shown potent dual PPAR activation. In ob/ob mice, it showed better efficacy than the comparator molecules. In fat fed rat model, it showed significant improvement in lipid parameters, which was better than fibrates.
