Preparation and Anticancer Effect of Pegylated-chlorambucil Prodrug Nanoparticle for Enhanced Therapeutic Efficiency
Eun-Hee Jeong, Gyeong-Won Jeong, Jae-Woon Nah
Index: 10.1016/j.jiec.2018.03.040
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Abstract
Chlorambucil (CLB), which is well known as a therapeutic agent of leukemia and Hodgkin’s disease, has been reported to have anticancer effects against various cancer cells. However, hydrophobic CLB has many problems, including being inefficient and producing side effects because of its low solubility in water. For these reasons, we developed a pegylated-CLB (PCLB and mPCLB) prodrug nanoparticle, which demonstrated excellent dispersibility, high anticancer activity and superior intracellular uptake. These results suggest that PCLB and mPCLB prodrug can use as anticancer agents against various cancer cells.