Diastereoselective Synthesis of Thieno [3′, 2′: 4, 5] cyclopenta [1, 2??d][1, 3] oxazolines− New Ligands for the Copper??Catalyzed Asymmetric Conjugate Addition of …

BF Bonini, E Capito, M Comes??Franchini…

Index: Bonini, Bianca Flavia; Capito, Elena; Comes-Franchini, Mauro; Ricci, Alfredo; Bottoni, Andrea; Bernardi, Fernando; Miscione, Gian Pietro; Giordano, Laurent; Cowley, Andrew R. European Journal of Organic Chemistry, 2004 , # 21 p. 4442 - 4451

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Citation Number: 14

Abstract

Abstract Several new ligands featuring a rigid three ring skeleton have been prepared for the first time following a modular approach. Chirality has been introduced by use of an oxazoline moiety fused with a cyclopenta [b] thiophene backbone. The efficiency and stereochemical impact of these ligands on the copper-catalyzed enantioselective addition of Et 2 Zn to chalcone was examined and enantiomeric excesses up to 79% were achieved ...