Synthesis of 2??substituted benzimidazoles by iodine??mediated condensation of orthoesters with 1, 2??phenylenediamines

ZH Zhang, JJ Li, YZ Gao, YH Liu

Index: Zhang, Zhan-Hui; Li, Jian-Jiong; Gao, Yuan-Zhe; Liu, Yu-Heng Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 6 p. 1509 - 1512

Full Text: HTML

Citation Number: 49

Abstract

The 2-substituted benzimidazole derivatives are important heterocyclic compounds, which exhibit a diverse range of biological properties such as antiviral, antitumour, antibacterial and anti-inflammatory activities [1]. They have also been used as ligands for asymmetric catalysis [2] and act as ligands to transition metals for modeling biological systems [3]. Therefore, the synthesis of this type of compounds has attracted considerable attention. ...