Exploitation of co-operative directed ortho-metallation (DoM) by 1, 3-related-OMOM groups in the development of a fully regio-controlled synthesis of atranol from …

MG Banwell, S Chand

Index: Banwell, Martin G.; Chand, Satish Organic Preparations and Procedures International, 2005 , vol. 37, # 3 p. 275 - 279

Full Text: HTML

Citation Number: 1

Abstract

In connection with efforts to develop a total synthesis of the fungal metabolite diversonol'we required access to atranol (5, Scheme I). The latter compound and its chloro derivative, both of which are powerful allergens, are themselves natural products and found as major components in oak moss absolute, an extract of the lichen Everia prunatri and an important ingredient in the perfumery industry? Atranol also represents a key sub-structure ...