e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Antiallergic Agents. 2. N-(1H-Tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides

…, K Hanamoto, H Nakai, H Inoue, A Ishida…

Index: Honma; Oda; Hashiyama; Hanamoto; Nakai; Inoue; Ishida; Takeda; Ono; Tsuzurahara Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1499 - 1504

Full Text: HTML

Citation Number: 20

Abstract

= H, OMe, C1) displayed remarkably high potencies in the rat PCA test on oral administration.'Our attention was next focused on exploring this lead in an effort to enhance the activity. In this paper we describe the synthesis and antiallergic activity of this new series of N-tetrazolylpyridinecarboxamides represented by general structure 1, which bears various substituents on the benzene and pyridine rings.

N-(5-tetrazolyl)-4-methyl-6-(4-N-methyl-N-benzyloxycarbonylaminophenyl)-2-pyridinecarboxamide Structure

N-(5-tetrazolyl...

~96%

N-(1H-tetrazol-5-yl)-4-methyl-6-(4-(methylamino)phenyl)-2-pyridinecarboxamide Structure

N-(1H-tetrazol-...

4-methyl-2-(4-nitrophenyl)pyridine Structure

4-methyl-2-(4-n...

~%

N-(1H-tetrazol-5-yl)-4-methyl-6-(4-(methylamino)phenyl)-2-pyridinecarboxamide Structure

N-(1H-tetrazol-...

6-(4-aminophenyl)-4-methylpicolinic acid Structure

6-(4-aminopheny...

~%

N-(1H-tetrazol-5-yl)-4-methyl-6-(4-(methylamino)phenyl)-2-pyridinecarboxamide Structure

N-(1H-tetrazol-...

4-methyl-2-(4-nitrophenyl)pyridine N-oxide Structure

4-methyl-2-(4-n...

~%

N-(1H-tetrazol-5-yl)-4-methyl-6-(4-(methylamino)phenyl)-2-pyridinecarboxamide Structure

N-(1H-tetrazol-...

N/A Structure

~%

N-(1H-tetrazol-5-yl)-4-methyl-6-(4-(methylamino)phenyl)-2-pyridinecarboxamide Structure

N-(1H-tetrazol-...

4-methyl-6-(4-nitrophenyl)-2-pyridinecarboxylic acid Structure

4-methyl-6-(4-n...

~%

N-(1H-tetrazol-5-yl)-4-methyl-6-(4-(methylamino)phenyl)-2-pyridinecarboxamide Structure

N-(1H-tetrazol-...

6-[4-[(benzyloxycarbonyl)methylamino]phenyl]-4-methyl-2-pyridinecarboxylic acid Structure

6-[4-[(benzylox...

~%

N-(1H-tetrazol-5-yl)-4-methyl-6-(4-(methylamino)phenyl)-2-pyridinecarboxamide Structure

N-(1H-tetrazol-...

ethyl 4-methyl-6-(4-benzyloxycarbonylaminophenyl)-2-pyridinecarboxylate Structure

ethyl 4-methyl-...

~%

N-(1H-tetrazol-5-yl)-4-methyl-6-(4-(methylamino)phenyl)-2-pyridinecarboxamide Structure

N-(1H-tetrazol-...

ethyl 6-(4-(((benzyloxy)carbonyl)(methyl)amino)phenyl)-4-methylpicolinate Structure

ethyl 6-(4-(((b...

~%

N-(1H-tetrazol-5-yl)-4-methyl-6-(4-(methylamino)phenyl)-2-pyridinecarboxamide Structure

N-(1H-tetrazol-...

ethyl 6-(4-aminophenyl)-4-methyl-2-pyridinecarboxylate hydrochloride Structure

ethyl 6-(4-amin...

~%

N-(1H-tetrazol-5-yl)-4-methyl-6-(4-(methylamino)phenyl)-2-pyridinecarboxamide Structure

N-(1H-tetrazol-...

5-Nitro-2-phenylpyridine Structure

5-Nitro-2-pheny...

~%

6-(4-Nitrophenyl)-picolinic acid Structure

6-(4-Nitropheny...

2-(4-nitrophenyl)pyridine 1-oxide Structure

2-(4-nitropheny...

~%

6-(4-Nitrophenyl)-picolinic acid Structure

6-(4-Nitropheny...

6-(4-ethylphenyl)-4-hydroxy-2-pyridinecarboxylic acid Structure

6-(4-ethylpheny...

~%

6-(4-Ethylphenyl)-picolinic acid Structure

6-(4-Ethylpheny...

ethyl 6-(4-ethylphenyl)-4-oxo-4H-pyran-2-carboxylate Structure

ethyl 6-(4-ethy...

~%

6-(4-Ethylphenyl)-picolinic acid Structure

6-(4-Ethylpheny...

ethyl 4-oxo-6-(p-tolyl)-4H-pyran-2-carboxylate Structure

ethyl 4-oxo-6-(...

~%

6-(P-TOLYL)PICOLINIC ACID Structure

6-(P-TOLYL)PICO...

4-chloro-6-(p-tolyl)picolinic acid Structure

4-chloro-6-(p-t...

~%

6-(P-TOLYL)PICOLINIC ACID Structure

6-(P-TOLYL)PICO...

N/A Structure

~%

6-(2-METHOXYPHENYL)PICOLINIC ACID Structure

6-(2-METHOXYPHE...