New imidazo [1, 2-a] quinoxaline derivatives: synthesis and in vitro activity against human melanoma

…, S Gayraud-Paniagua, F Bressolle, F Pinguet…

Index: Deleuze-Masquefa, Carine; Moarbess, Georges; Khier, Sonia; David, Nadege; Gayraud-Paniagua, Stephanie; Bressolle, Francoise; Pinguet, Frederic; Bonnet, Pierre-Antoine European Journal of Medicinal Chemistry, 2009 , vol. 44, # 9 p. 3406 - 3411

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Citation Number: 27

Abstract

New imidazo [1, 2-a] quinoxaline analogues have been synthesized in good yields via a bimolecular condensation of 2-imidazole carboxylic acid, followed by a coupling with ortho- fluoroaniline and subsequent substitution on the imidazole ring by Suzuki Cross-coupling reaction using microwave assistance. Antitumor activities of these derivatives were evaluated by growth inhibition of A375 cells in vitro. All compounds exhibited high ...