Treatment of carbonyl derivatives with 2,2-difluorovinyl lithium, quantitatively prepared in situ from 1,1-difluoroethylene and s-Buli ( , −100°C) 1 , leads to the alcohols . These are relatively unstable and mut be used crude quickly, due to their tendency to undergo a rapid allylic migration to yield unsaturated acid fluorides 5 . To the lithium alcoholates of (0.02 mol) (obtained by metallation of (0.02 mol) with MeLi (0.02 mol) in Et 2 O (50 ml)), is added LiAlH 4 (0.013 mol) (4 h, rt) ...
