Bioorganic & medicinal chemistry

Synthesis of N-substituted N-nitrosohydroxylamines as inhibitors of mushroom tyrosinase

M Shiino, Y Watanabe, K Umezawa

Index: Shiino, Mitsuhiro; Watanabe, Yumi; Umezawa, Kazuo Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1233 - 1240

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Citation Number: 133

Abstract

A series of N-substituted N-nitrosohydroxylamines including six new compounds were synthesized and examined for inhibition of mushroom tyrosinase. Corresponding hydroxylamines were reacted with n-butyl nitrite to give substituted nitrosohydroxylamines as their ammonium salt. The N-substituted hydroxylamines were prepared from the primary amines via the oxaziridine, or from the carbonyl compounds via the oxime. Most of the ...