Synthetic communications

A rapid conversion of 3-oxothiolanes into 3-aminothiophenes

JM Barker, PR Huddleston, ML Wood

Index: Barker, John M.; Huddleston, Patrick R.; Wood, Michael L. Synthetic Communications, 2002 , vol. 32, # 16 p. 2565 - 2568

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Citation Number: 7

Abstract

3-Oxotetrahydrothiophenes can be rapidly converted into 3-aminothiophenes by refluxing with hydroxylamine hydrochloride in a polar solvent, usually acetonitrile. ... 3-Oxotetrahydrothiophenes can be rapidly converted into 3-aminothiophenes by refluxing with hydroxylamine hydrochloride in a polar solvent, usually acetonitrile. ... The process requires only a few hours and generally results in good yields. Presumably the reaction occurs by HCl liberated from the oxime ...