Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole

XD Yang, WC Wan, XY Deng, Y Li, LJ Yang, L Li…

Index: Yang, Xiao-Dong; Wan, Wei-Chao; Deng, Xiao-Yan; Li, Yan; Yang, Li-Juan; Li, Liang; Zhang, Hong-Bin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2726 - 2729

Full Text: HTML

Citation Number: 17

Abstract

A series of novel hybrid compounds between 2-phenylbenzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-3-position with a naphthylacyl or bromophenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 15 was found to be the most potent compound against 4 strains human tumor cell lines and more ...