Enzymatic resolution of (RS)-β-hydroxy selenides in organic media

CE Costa, GC Clososki, HB Barchesi, SP Zanotto…

Index: Costa, Carlos E.; Clososki, Giuliano C.; Barchesi, Henrique B.; Zanotto, Sandra P.; Nascimento, M. Graca; Comasseto, Joao V. Tetrahedron Asymmetry, 2004 , vol. 15, # 24 p. 3945 - 3954

Full Text: HTML

Citation Number: 30

Abstract

Kinetic resolutions of a number of β-hydroxy selenides promoted by enzymes were performed using PPL (free Porcine pancreatic lipase), PSL (Amano PS—free Pseudomonas sp. lipase) and CALB (NOVOZYM 435®—immobilized Candida Antarctica lipase type B) with (RS)-1-phenylselanyl-propan-2-ol. CALB gave the best results and provided both (R)- and (S)-enantiomers in high enantiomeric purity. A comparative study of the effect of ...