The synthesis and Gly/NMDA, AMPA and KA receptor binding activities of some 3-hydroxy- quinazoline-2, 4-dione derivatives are reported. The binding data, together with functional antagonism studies, showed that the 3-hydroxy-quinazoline-2, 4-dione moiety can be considered a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists. In fact, introduction of chlorine atom (s) on precise position (s) of the benzofused moiety ...
