Defined substrates for human embryonic stem cell growth identified from surface arrays

…, RL Lewis, JA Thomson, LL Kiessling

Index: Orner, Brendan P.; Derda, Ratmir; Lewis, Rachel L.; Thomson, James A.; Kiessling, Laura L. Journal of the American Chemical Society, 2004 , vol. 126, # 35 p. 10808 - 10809

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Citation Number: 141

Abstract

Methods for the rapid identification of defined cell growth conditions are lacking. This deficiency is a major barrier to the investigation and application of human embryonic stem (ES) cells. To address this problem, we developed a method for generating arrays of self- assembled monolayers (SAMs) in which each element constitutes a defined surface. By screening surface arrays, we identified peptidic surfaces that support ES cell growth and ...