Nano Today 2018-02-13

Reassessment of nanomaterials immunotoxicity

Mahmoud Elsabahy, Karen L. Wooley

Index: 10.1016/j.nantod.2018.01.002

Full Text: HTML

Abstract

Biomarkers (e.g. cytokines) that are commonly measured to assess the immunomodulatory effects of nano- or micro-particulates may be adsorbed on their surfaces and/or absorbed within internal regions, thereby, generating an inaccurately low measure of immunotoxic effect. We provide this commentary, therefore, as a cautionary recommendation that previously published data be reassessed, and future investigations consider potential artifacts and data misinterpretation carefully.