Tetrahedron Letters

Facile synthesis of benzoxazoles from 1, 1-dibromoethenes

K Tao, J Zheng, Z Liu, W Shen, J Zhang

Index: Tao, Kemei; Zheng, Jianlong; Liu, Zhaogui; Shen, Wang; Zhang, Jiancun Tetrahedron Letters, 2010 , vol. 51, # 24 p. 3246 - 3249

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Citation Number: 12

Abstract

Direct coupling of 1, 1-dibromoethenes with 2-aminophenols had been achieved to form the corresponding benzoxazoles under mildly basic reaction conditions. A variety of substituted 2-aminophenols provided the desired products in moderate to good yields. Even though 1, 1- dibromoethenes have to be derived from arylcarboxaldehydes or glyoxalate for the reactions, this method still provides a new route to the preparation of benzoxazoles, ...