Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(mercaptomethyl)-2-oxo-1- …

…, ML Hoefle, RD Smith, AD Essenburg…

Index: Klutchko, Sylvester; Hoefle, Milton L.; Smith, Ronald D.; Essenburg, Arnold D.; Parker, Robert B.; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 104 - 109

Full Text: HTML

Citation Number: 33

Abstract

The compound was prepared in 47% yield using a procedure similar to that described for lob: yellow crystals; mp 115-117" C (CH2C12-petroleum ether); IR (KBr) 1716 cm- *(COOC2H5); W max (EtOH) 208 nm (t 24500), 365 (45400);'H NMR (CDCl,) 6 6.76 [d, J= 16 Hz,(E)-ArCH= CH], 6.55 (d, J= 12 Hz, CH3C= CH), 6.47 (d, J= 16 Hz, ArCH= CH), 6.38 (dd, JHH=