Synthesis and evaluation of tacrine–E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease

D Shao, C Zou, C Luo, X Tang, Y Li

Index: Shao, Dong; Zou, Chunyan; Luo, Cheng; Tang, Xican; Li, Yuanchao Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 18 p. 4639 - 4642

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Citation Number: 67

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Tacrine–E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro. ... Tacrine-E2020 hybrids and some ...

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