Synthesis

A new focused microwave approach to the synthesis of amino-substituted pyrroloisoquinolines and pyrroloquinolines via a sequential multi-component coupling …

MD Hopkin, IR Baxendale, SV Ley

Index: Hopkin, Mark D.; Baxendale, Ian R.; Ley, Steven V. Synthesis, 2008 , # 11 p. 1688 - 1702

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Citation Number: 10

Abstract

Abstract A multi-component reaction has been developed allowing direct access to pyrroloisoquinolines and pyrroloquinolines with new, electron-rich substitution patterns. The synthesised amino-substituted heterocyclic compounds and intermediates involved in their formation represent novel compounds. Focused microwave irradiation was used extensively to allow simple access to a wide temperature range using low boiling point solvents.