Abstract A series of steroidal estrogen antagonists with no intrinsic estrogenicity in rat uterotrophic-antiuterotrophic tests has been discovered. The compounds are derivatives of estradiol containing amidoalkyl side chains at the 7α-position. The most potent compounds are Nn-butyl-N-methyl-11-(3, 17β-dihydroxyestra-1, 3, 5 (10)-trien-7α-yl) undecanamide and N-2, 2, 3, 3, 4, 4, 4-heptafluorobutyl-N-methyl-11-(3, 17β-dihydroxyestra-1, 3, 5 (10)-trien- ...
