N-and 2-substituted N-(phenylsulfonyl) glycines as inhibitors of rat lens aldose reductase

J DeRuiter, RF Borne, CA Mayfield

Index: DeRuiter, Jack; Borne, Ronald F.; Mayfield, Charles A. Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 145 - 151

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Citation Number: 26

Abstract

Scheme I. The N-(substituted-phenylsulfonyl)-N-phenylglycines can be obtained directly by reaction of 8 with N-phenylglycine 9 in aqueous THF containing 2 equiv of base. Alternatively, the N-(phenylsulfonyl)-N-(sub-stituted-pheny1) glycines were prepared in a multistep sequence via the intermediate sulfonamides ll (Scheme I). Reaction of 8 with anilines 10 in dichloromethane using triethylamine base provided the intermediate ...