One??step preparation of 3??alkoxypyrazine??2??carbonitriles from pyrazine??2, 3??dicarbonitriles and related reactions

T Kojima, F Nagasaki, Y Ohtsuka

Index: Kojima, Takakazu; Nagasaki, Fumihiko; Ohtsuka, Yozo Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 455 - 459

Full Text: HTML

Citation Number: 7

Abstract

Abstract A series of 5, 6-disubstituted 3-alkoxypyrazine-2-carbonitriles (2a-i) were prepared from 5, 6-disubstituted pyrazine-2, 3-dicarbonitriles (1a-d) by direct substitution with alcohols. Treatment of 1 with amines gave either pyrrolopyrazines (3a, b) or substitution products (4, 5). In a low temperature range, 1 afforded imidates and related compounds (6– 11). The preference among these reactions depended on the 5, 6-substituents and on the ...