Searching for novel antiobesity agents, a series of cannabinoid LH21 and of Rimonabant- fatty acid amide analogues have been prepared. Synthesis of pyrazoles 2a–2c was achieved by a two steps simple methodology via α, β-unsaturated ketones. Carboxamides 8a–8h were obtained in good yields from esters 7a–7c by a one-pot procedure which takes place under mild conditions. New compounds have been evaluated in vivo as anorectic ...
[Hernandez-Vazquez, Eduardo; Aguayo-Ortiz, Rodrigo; Ramirez-Espinosa, Juan Jose; Estrada-Soto, Samuel; Hernandez-Luis, Francisco European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 10 - 21]
