Journal of medicinal chemistry

Hypocholesterolemic Agents. Thyroalkanols

WJ Wechter, WA Phillips, F Kagan

Index: Wechter,W.J. et al. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 474 - 478

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Citation Number: 6

Abstract

11) 11\ ist ('tii di (> ri. OII toxicity.'"(:<) Aic* tylatioit 01 htli (lie pheiiolic arid alcoholic hydrosyl groups of 1 had iio cffcct on either hypocholestcroleinic activity or tosivity ((f. 1 us. 2).(4) Removal of the 4'-hydroxyl group aid substitution of hydrogcii 111 8 and 1 destroyed activity"((j. 8 us. 10 atid 1 cs. 4).(-5) Iieiiioval of thr:~'.. i'-~ ubstituei~ ts iii the thyroalkanols reduced hypo-caholest croleniic potency (cf. 0.3-iiig.'kg. dose in 12). 1iit1duc. t ioii of ci ...