Bioorganic & medicinal chemistry letters

Design and synthesis of novel 7-aminoquinazoline derivatives: antitumor and anticonvulsant activities

AS El-Azab, KEH ElTahir

Index: El-Azab, Adel S.; Eltahir, Kamal E.H. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1879 - 1885

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Citation Number: 40

Abstract

A novel series of 7-substituted-4 (3H)-quinazolinone were designed, synthesized and evaluated for their antitumor and anticonvulsant activity. Compound 7 revealed broad- spectrum antitumor effectiveness toward numerous cell lines that belong to different tumor subpanels, whereas compounds 9 and 18 possess selective activity toward leukemia cell lines. Additionally, compounds 3, 15, 16, 18, 19 and 20 showed advanced anticonvulsant ...