Analysis of intact glucuronides and sulfates of serotonin, dopamine, and their phase I metabolites in rat brain microdialysates by liquid chromatography− tandem mass …

P Uutela, R Reinilä, K Harju, P Piepponen…

Index: Uutela, Paeivi; Reinilae, Ruut; Harju, Kirsi; Piepponen, Petteri; Ketola, Raimo A.; Kostiainen, Risto Analytical Chemistry, 2009 , vol. 81, # 20 p. 8417 - 8425

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Citation Number: 52

Abstract

A method for the analysis of intact glucuronides and sulfates of common neurotransmitters serotonin (5-HT) and dopamine (DA) as well as of 5-hydroxy-3-indoleacetic acid (5-HIAA), 3, 4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) in rat brain microdialysates by liquid chromatography− tandem mass spectrometry (LC− MS/MS) was developed. Enzyme-assisted synthesis using rat liver microsomes as a biocatalyst was ...