e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Tetrahedron Letters

An efficient, continuous flow technique for the chemoselective synthesis of thioacetals

C Wiles, P Watts, SJ Haswell

Index: Wiles, Charlotte; Watts, Paul; Haswell, Stephen J. Tetrahedron Letters, 2007 , vol. 48, # 41 p. 7362 - 7365

Full Text: HTML

Citation Number: 15

Abstract

By optimizing a reagent's residence time within a packed-bed reactor, it is possible to overcome selectivity issues frequently encountered in stirred reaction vessels. This important feature is demonstrated for the chemoselective protection of 4- acetylbenzaldehyde whereby 1-[4-1, 3-dithian-2-yl-phenyl] ethanone is obtained in excellent yield and purity. In addition, the generality of the technique is highlighted via the protection ...

1,2-Ethanedithiol Structure

1,2-Ethanedithiol

2-Naphthaldehyde Structure

2-Naphthaldehyde

~99%

2-naphthalen-2-yl-1,3-dithiolane Structure

2-naphthalen-2-...

1,3-Propanedithiol Structure

1,3-Propanedithiol

Cyclohexanone Structure

~99%

1,5-Dithiaspiro[5.5]undecane Structure

1,5-Dithiaspiro...

1,2-Ethanedithiol Structure

1,2-Ethanedithiol

4-Nitroacetophenone Structure

4-Nitroacetophenone

~98%

2-methyl-2-(4-nitrophenyl)-1,3-dithiolane Structure

2-methyl-2-(4-n...

1,3-Propanedithiol Structure

1,3-Propanedithiol

3,5-Dimethoxybenzaldehyde Structure

3,5-Dimethoxybe...

~99%

2-(3,5-dimethoxyphenyl)-1,3-dithiane Structure

2-(3,5-dimethox...

1,3-Propanedithiol Structure

1,3-Propanedithiol

4-Bromobenzaldehyde Structure

4-Bromobenzaldehyde

~99%

2-(4-bromophenyl)-1,3-dithiane Structure

2-(4-bromopheny...

1,3-Propanedithiol Structure

1,3-Propanedithiol

4-Cyanobenzaldehyde Structure

4-Cyanobenzaldehyde

~97%

4-(1,3-dithian-2-yl)benzonitrile Structure

4-(1,3-dithian-...

1,3-Propanedithiol Structure

1,3-Propanedithiol

Benzophenone Structure

~99%

2,2-diphenyl-1,3-dithiane Structure

2,2-diphenyl-1,...

1,3-Propanedithiol Structure

1,3-Propanedithiol

2-Naphthaldehyde Structure

2-Naphthaldehyde

~98%

2-naphthalen-2-yl-1,3-dithiane Structure

2-naphthalen-2-...

1,2-Ethanedithiol Structure

1,2-Ethanedithiol

1-Phenylbutan-1-one Structure

1-Phenylbutan-1-one

~99%

2-phenyl-2-propyl-1,3-dithiolane Structure

2-phenyl-2-prop...

1,2-Ethanedithiol Structure

1,2-Ethanedithiol

4-Cyanobenzaldehyde Structure

4-Cyanobenzaldehyde

~99%

4-(1,3-dithiolan-2-yl)benzonitrile Structure

4-(1,3-dithiola...

1,3-Propanedithiol Structure

1,3-Propanedithiol

Acetophenone Structure

~99%

1,3-Dithiane,2-methyl-2-phenyl- Structure

1,3-Dithiane,2-...

1,3-Propanedithiol Structure

1,3-Propanedithiol

4-Nitroacetophenone Structure

4-Nitroacetophenone

~98%

2-methyl-2-(4-nitrophenyl)-1,3-dithiane Structure

2-methyl-2-(4-n...

1-(4-Chlorophenyl)ethanone Structure

1-(4-Chlorophen...

1,2-Ethanedithiol Structure

1,2-Ethanedithiol

~99%

1,3-DITHIOLANE, 2-(p-CHLOROPHENYL)-2-METHYL- Structure

1,3-DITHIOLANE,...

1,3-Propanedithiol Structure

1,3-Propanedithiol

4-Biphenylcarbaldehyde Structure

4-Biphenylcarba...

~99%

2-(4-phenylphenyl)-1,3-dithiane Structure

2-(4-phenylphen...